TeachMeFinance.com - explain Tetraploid complementation assay
Tetraploid complementation assay The term 'Tetraploid complementation assay' as it applies to the area of stem cell research can be defined as 'An assay that can be used to test a stem cell's potency. Scientists studying mouse chimeras (mixing cells of two different animals) noted that fusing two 8-cell embryos produces cells with 4 sets of chromosomes (tetraploid cells) that are biased toward developing into extra-embryonic tissues such as the placenta. The tetraploid cells do not generate the embryo itself; the embryo proper develops from injected diploid stem cells. This tendency has been exploited to test the potency of a stem cell. Scientists begin with a tetraploid embryo. Next, they inject the stem cells to be tested. If the injected cells are pluripotent, then an embryo develops. If no embryo develops, or if the resultant embryo cannot survive until birth, the scientists conclude that the cells were not truly pluripotent'.
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