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TeachMeFinance.com - explain CA-125 test CA-125 test -- A blood test that measures the level of CA-125, a substance found in blood, other body fluids and some tissues. Increased levels of CA-125 may be a sign of cancer. Copyright © 2005 by Mark McCracken, All Rights Reserved. TeachMeFinance.com is an informational website, and should not be used as a substitute for professional medical, legal or financial advice. Information presented at TeachMeFinance.com is provided on an "AS-IS" basis. Source of definition: The National Cancer Institute. Please read the disclaimer for details.